RESEARCH

The sky's the limit (unless you're an astronaut)!

C-H FUNCTIONALIZATION USING CARBON DIOXIDE AND CARBOXYLIC ACIDS

Our lab has pioneered the use of carbon dioxide (in the form of dry ice) as a transient directing group to achieve site selective C–H functionalization. Early indications are that carbon dioxide actually plays multiple roles in these reactions. Current research in our group aims to better understand how and why these reactions work, as well as to expand the scope of chemical disconnections that can be achieved on various heteroatom-containing substrates by addition of carbon dioxide and transition metal catalysts.

SYNTHESIS AND APPLICATIONS OF SUPRAMOLECULAR STRUCTURES

We are interested in developing new metal-organic frameworks (MOFs) and metal-organic polyhedra (MOPs) for applications in sensing, catalysis, and drug delivery.

HYDROGEN BOND DIRECTED CATALYSIS

A new area in our group is to develop new remote or distal functionalizations of unactivated C–H bonds. To do this, we will target unconventional strategies for how directing groups interact with a catalyst to achieve site-selective C–H functionalization. These approaches are anticipated to have significant impact on drug discovery by allowing facile late stage functionalization of complex substrates, as well as for more sustainable synthesis of polymer precursors from renewable feedstocks.

DRUG DESIGN

Using methodology developed in our lab, we are planning to start a program looking at the activity of small molecule amine and alcohol libraries against various disease and antibacterial targets.

 

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