THE YOUNG LAB AT THE UNIVERSITY OF TOLEDO

RECENT NEWS

NEW PAPER: 3,3-DIARYLALLYLAMINES ENABLED BY CO2 AS A TRANSIENT PROTECTING GROUP

December 1, 2020

Congrats to Vinod and Justin, as well as the rest of the team, for their tireless work on the arylation of cinnamylamines (and diarylation of allylamines) under Pd nanoparticle catalysis. The reaction is simple to execute, and the key is that CO2 slows decomposition, allowing reproducible reaction yields.

NEW PAPER: THAT DOESN'T GO THERE?!? OKAY, WELL IT DOES NOW!

December 1, 2020

Congrats to Vinod, Kendra, and Aaron for their recent work out in Organic Letters! While trying to access deuterated compounds for another study, our group realized a relatively simple protocol for H/D exchange at the alpha-position of Michael acceptors including enals and enones. The reaction set-up is simple, and the work-up doesn't need a column in many cases. Furthermore, the reagents are readily available!

NEW PAPER: A SIDE REACTION TURNS INTO A COOL PROJECT

April 22, 2020

Congrats to Pratibha, Vinod, and Mohit for their recent work out in J. Org. Chem. Whilst evaluating the substrate scope of our previous benzylamine arylation paper, we found that ortho-iodo benzoate esters actually gave rise to C‒H activation followed by concomitant lactamization. Moreover, due to chelation assistance in the C‒I oxidative addition step, no additional directing group is needed!