Welcome to the Young Group at The University of Toledo
Overview of Our Research
Research in The Young Lab focuses on applying supramolecular principles towards greener transition metal catalysis with a special emphasis on C–H activation and new ligands for supporting traditional catalysts.
Can You Smell What The Young Lab's Been Cookin'?
Rh(III)-Catalyzed H/D Exchange on Carboxylic Acids
Congrats to Alyssa and Hanyang for their recent manuscript in Org. Lett.! The manuscript describes a protocol for the ortho-deuteration of aromatic carboxylic acids using only deuterium oxide as both solvent and deuterium source, and features low (~1 mol%) catalyst loadings.
Carbon Dioxide-Mediated C-H Arylation of 1º and 2º Benzylamines
Congrats to Mohit and Pratibha for their recently accepted article in J. Am. Chem. Soc.! The manuscript describes a protocol for the ortho-arylation of benzylamines with aryl iodides using palladium acetate as a catalyst, with a crucial role for carbon dioxide that lowers the reaction temperature by 30 ºC compared with the native amine, and which allows greatly increased substrate scope.
Review of Recent Catalytic Applications in Carboxylate-Based Metal Organic Frameworks
Congrats to Allison and Jared for their recently accepted book chapter in the ACS Symposium Series. The chapter is a review of recent applications of MOFs (built on carboxylate linkers and various metal vertices) towards catalysis, from CO2 activation to C-H activation, to photocatalysis.
Self-Assembled Capsules Experiment for Undergraduate Lab
Congrats to Daniel and our collaborators Katherine Pappano, John Payton, and Richard Hooley for the recent acceptance of a new supramolecular lab procedure in the Journal of Chemical Education. The experiment provides a convenient platform for studying supramolecular chemistry at the undergraduate level, including a cool exploration of host:guest chemistry demonstrated by proton NMR.
Highlight of our Carbon Dioxide-Mediated C–H Activation Work
Congrats to Mohit, Pratibha, Justin, Daniel, and Hanyang for their recent publication published in Synlett. This manuscript highlights our recent work using carbon dioxide in C–H activation, and frames it within the context of other transient directing group approaches.
Good-bye Dr. Kapoor!
It is with mixed emotions that we say good-bye to Dr. Mohit Kapoor. Mohit was a postdoc in our lab from April 2017 - December 2018, where he was integral to getting our carbon dioxide-mediated C–H activation work off of the ground, and contributed to the discovery of numerous disconnections. Dr. Kapoor is off to take a position at Chitkara University where he will lead his own research group. Congrats Prof. Mohit!
One-Dimensional Networks Using Anthracene Dibenzoate Ligands and Zn(II)
Congrats to Ms. Allison Rabon and Project SEED student Ms. Kayla Goolsby for their recent paper in ActaCrystC! This work demonstrates what can happen when weak intermolecular forces out-compete perceived more thermodynamically-preferred dative bonds.
Primer on Using Dry Ice in Reaction Vials
Congrats to Dr. Mohit Kapoor, Ms. Pratibha Chand-Thakuri, and Mr. Justin Maxwell for their paper published in JoVE! This work is a great demonstration of how easy it is to use dry ice to achieve moderate pressures of carbon dioxide in simple reaction vessels without the need for complicated equipment.
Carbon Dioxide-Direct C–H Arylation of Aliphatic Amines
Congrats to Dr. Mohit Kapoor and Mr. Daniel Liu for their paper published in JACS!